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Oleoylethanolamide (OEA)

Overview

 

Oleoylethanolamide (OEA) is a naturally occurring lipid mediator belonging to the fatty acid ethanolamide (FAE) family. It is biosynthesized in the small intestine from oleic acid and ethanolamine. Unlike other endocannabinoid-related compounds, OEA does not activate cannabinoid receptors (CB1/CB2), but instead serves as a potent agonist of peroxisome proliferator-activated receptor alpha (PPAR-α). This unique mechanism underlies its role in regulating appetite, lipid metabolism, and body weight control.

  • ⚙️ Key Specifications

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  • Name: Oleoylethanolamide (OEA)

  • Synonyms: N-Oleoylethanolamine, N-[(Z)-9-octadecenoyl]ethanolamine

  • Molecular Formula: C20H39NO2

  • Molecular Weight: 321.53 g/mol

  • CAS Number: 111-58-0

  • Purity: ≥80-90% (HPLC)

  • Appearance: White to off-white powder

  • Storage: Keep in a cool, dry, and light-protected environment

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  • 🌿 Mechanism of Action

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  • PPAR-α Activation

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  • OEA binds to and activates PPAR-α, a nuclear receptor that regulates lipid metabolism and satiety signals.

  • Appetite Regulation

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  • Stimulates vagus nerve signaling, leading to reduced meal size and prolonged satiety.

  • Metabolic Modulation

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  • Enhances fatty acid oxidation and reduces fat storage.

  • Helps improve lipid profile by lowering triglycerides and supporting healthy cholesterol levels.

  • Neuroprotection

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  • Exhibits antioxidant and anti-inflammatory effects in neural tissue, with potential cognitive benefits.

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  • 💊 Health Benefits & Applications

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  • Weight Management

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  • Clinically studied for its ability to reduce food intake and promote fat metabolism.

  • Metabolic Health

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  • Supports lipid metabolism and cardiovascular well-being.

  • Anti-Inflammatory & Neuroprotective

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  • Potential roles in reducing oxidative stress and protecting against neurodegenerative conditions.

  • Sports Nutrition

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  • Enhances energy utilization and fat burning, beneficial for athletes and fitness applications.

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  • 🏭 Application Areas

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  • Nutraceuticals & Dietary Supplements

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  • Capsules, tablets, softgels for weight management and metabolic support.

  • Functional Foods & Beverages

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  • Incorporated into health drinks and nutrition bars.

  • Pharmaceutical Research

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  • Investigated for obesity, metabolic syndrome, and neurodegenerative diseases.

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  • ✅ Advantages of Our OEA

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  • High purity (≥80-90%, HPLC validated)

  • Stable and consistent quality

  • Backed by scientific studies on appetite and lipid metabolism

  • Suitable for dietary supplement, functional food, and R&D markets

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  • ⚠️ Regulatory Note:

  • OEA is marketed as a dietary supplement ingredient in the U.S. and some countries, but classification may vary by region. It is not intended to diagnose, treat, cure, or prevent any disease.

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